Recently, we reported that SFN metabolites induced apoptosis and inhibited migration and invasion via causing microtubule disruption7,13,25; here we further determined that SFN-Cys inhibited the invasion in GBM by phosphorylated ERK1/2-mediated downregulation of Stathmin-1 and α-tubulin, and microtubule disruption. This evidence concerns the gene STMN1 and glioblastoma.