CLDN5 and glioblastoma: Of these, gene expression analysis by GEPIA server showed that the expressions of TUBA1C, S100A4, CLDN5 (Claudin-5), MAPK1, LAMP1, LAMP2, BNIP3L (Nix), MAP1LC3B (LC3), PODXL, MMP-2, ITGB3, CD47, and FN1 were upregulated, while SEMA7A expression was downregulated in GBM tissues (Fig. 1b).