Results showed that SFN-Cys downregulated α-tubulin in a dose-dependent manner in GBM cells (Fig. 3a), while such downregulation was reversed by PD98059 (25 μM) (Fig. 3b), indicating that SFN-Cys downregulated α-tubulin by the phosphorylation of ERK1/2. This evidence concerns the gene MAPK3 and glioblastoma.