SOX17 and pulmonary arterial hypertension: The risk SNP rs1995535 is located in the RE chr8:55246176-55252419, which is about 118 kb upstream to TSS of SOX17. vPECA links this risk SNP to SOX17 rather than the nearest gene LOC729038. Another PAH associated locus rs10103692 (8:55258127: G/A), located 5 kb near our identified RE, is in an enhancer region that specifically regulates the expression of SOX17 in endothelial cells33.