IGFBP3 and retinal disorder: The mRNA expression profile at P17 was comparable to the expression at P12, with more than a 2-fold decrease of Igf1 and Igfbp3 in the hyperglycemic oxygen-induced retinopathy versus normoglycemic oxygen-induced retinopathy groups (both < 0.0001); Igfbp1 mRNA expression was the same in each group (Figure 5E).