Further, we assessed plasma glucose levels, liver mRNA expression of Igf1, insulin-binding protein 3 (Igfbp3), and insulin-binding protein 1 (Igfbp1), and plasma levels of IGF1 in the neonatal hyperglycemic oxygen-induced retinopathy versus normoglycemic oxygen-induced retinopathy mice at P12 and P17. The gene discussed is IGFBP3; the disease is retinal disorder.