After adjustment for confounders, comparing with No-DM group, the risk of AKI in DM-insulin group was close to 4-fold (OR 3.92, 95% CI 3.27–5.16); the risk of AKI in DM-oral group was 1.26, smaller but still significant (OR 1.26, 95% CI, 1.03–1.57). The gene discussed is INS; the disease is acute kidney injury.