PAPPA and type 2 diabetes mellitus: Single factor analysis shows that age, gender, smoking, hypertension, T2DM, HDL-C, MMP-9, LOX-1, YKL-40, PAPP-A, Lipids ratio and 10-year ICVD values have statistically significant difference (P < 0.05) between patients without plaque and those with plaque, as shown in Table 1.