Moreover, patients with LD show significantly impaired parameters of glucose control (i.e., increased glycosylated hemoglobin A1c [HbA1c], fasting glucose [FG], fasting insulin [FI], and homeostasis model assessment of insulin resistance [HOMA-IR]) and lipid metabolism (i.e., decreased high density lipoprotein [HDL] cholesterol, increased triglycerides [TG], increased free fatty acids [FFA]) as compared to the control cohort (p < 0.05; Table 1). This evidence concerns the gene INS and Insulin resistance.