Cytokines IL-4, IL-8 and TNF-α are significantly elevated (p = 0.012, 0.033 and 0.0291, respectively) in FD subjects with IRRs when compared to control group (Figure 3A–C), indicating the degranulation of mast cells upon exposure to recombinant protein. The gene discussed is CXCL8; the disease is Fabry disease.