NCSTN and chronic myelomonocytic leukemia: Genetic loss of NCSTN and the chemical inhibition of the γ-secretase complex in murine bone marrow or cord blood cells induce a hematopoietic phenotype similar to that of chronic myelomonocytic leukemia (CMML), with the aberrant accumulation of granulocyte/monocyte progenitors and extramedullary hematopoiesis [159].