Consistently, trichostatin A, a pan HDAC inhibitor, reduces the level of N3-FL, N3-TM, and N3-ICD in two different human T-ALL cell lines and in different patient-derived xenografts (PDX), causing the transcriptional suppression of NOTCH3 target genes, such as pre-T cell receptor α (pTα), complement receptor (CR) 2 and DTX1 [167]. Here, NOTCH3 is linked to acute lymphoblastic leukemia.