Subsequently, Roti and Stegmaier confirmed these observations in a mammalian model of NOTCH1 mutated T-ALL by integrating NOTCH gain- and loss-of-function screening approaches to identify inhibitors of oncogenic NOTCH1 signatures or enhancer of NOTCH1 HD mutant L1601P∆P activity [170]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.