While miR-328 has been shown to mediate the invasiveness of glioma cells via the downregulation of Secreted Frizzled-related protein 1 (SFRP1) [44], Ebrahimkhani et al. reported that serum EVs from glioblastoma patients exhibited lower levels of miR-328 compared to HV [34]. Here, SFRP1 is linked to central nervous system cancer.