TTR and AL amyloidosis: More than 30 proteins can misfold and deposit in tissues as amyloid fibrils, but almost all clinical cases of CA are from either misfolded monoclonal immunoglobulin light chains from an abnormal clonal proliferation of plasma cells (AL amyloidosis, also known as primary systemic) [56], or transthyretin (ATTR amyloidosis), a protein synthesized by the liver and normally involved in the transportation of the hormone thyroxine and retinol-binding protein [57].