FLT3 and myeloproliferative neoplasm: In contrast in mice, Flt3 transcripts and FLT3 protein were detected in the LT-HSC compartment suggesting a previously unrecognized role of FLT3 in LT-HSC homeostasis and establishes an intrinsic link between normal stem cell quiescence/homeostasis and development of myeloproliferative neoplasm [58].