To decipher the molecular mechanisms involved in the transition from the chronic phase to blast crisis in chronic myelogenous leukemia (CML), gene expression profiles at diagnosis in patients at the chronic phase and in blast crisis showed that increased abundance of FLT3-expressing cells attenuated imatinib-induced apoptosis [76]. Here, FLT3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.