Mutations leading to the loss of the retinoblastoma transcriptional corepressor 1 gene (RB1) or deregulation of its gene product, the retinoblastoma tumor suppressor protein (pRB), are associated with several forms of cancer including retinoblastoma, osteosarcoma, adenocarcinomas, small cell lung cancer, breast cancer, prostate cancer, and others [1]. Here, RB1 is linked to Familial prostate cancer.