Compared with male APP/PS1/tau triple-transgenic AD mice, AD female mice exhibit more prominent Aβ plaques, neurofibrillary tangles, neuroinflammation, spatial cognitive deficits, and dysregulation of hippocampal cyclic adenosine monophosphate (cAMP)-response element (CRE)-binding protein (CREB) signaling. The gene discussed is CREB1; the disease is Alzheimer disease.