Evolving evidence indicates that RJ-related induction of BDNF signaling may alleviate AD symptoms in APP/PS1 mice by reducing cortical and hippocampal levels of BACE1, soluble and insoluble Aβ40 and Aβ42, as well as the number and size of Aβ plaques [28]. The gene discussed is BACE1; the disease is Alzheimer disease.