The activation and blockade of GABA B receptor by baclofen and phaclofen at a low dose (0.1 μg/rat) potentiated memory impairment induced by simultaneous administration of low doses of D-AP5 (0.0625 and 0.125 μg/rat); however, they abolished the memory impairment effect of higher D-AP5 doses (0.25 μg/rat). The gene discussed is GABBR1; the disease is memory impairment.