SQSTM1 and Alzheimer disease: Research reports impaired autophagic influx under inflammatory conditions in AD mice [173]; 10-HDA was reported to promote autophagic immune regulation and evoke autophagy in activated microglia and LPS-treated mice by upregulating both Unc-51-like autophagy activating kinase (ULK) and microtubule-associated protein 1 light chain 3-II (LC3-II) and inhibiting sequestosome 1 (SQSTM1/p62).