PSEN1 and Alzheimer disease: It also corrected cognitive deficits in different AD models such as copper and cholesterol-fed rabbits [70], streptozotocin-induced hippocampal neuronal death [111], trimethyltin-induced hippocampal neuronal death [112], and double transgenic APP/PS1 mice, which express two mutations associated with early-onset AD—chimeric mouse/human APP (Mo/HuAPP695swe) and human PS1 (PS1-dE9) [28].