MAPT and tauopathy: In this respect, the formation of Aβ plaques is significantly associated with proteotoxicity and tauopathy, i.e., protein misfolding, hyperphosphorylation and nucleation of axonal tau proteins, resulting in a wide spread of twisted strands of the tau protein and the formation of neurofibrillary tangles (NFTs) inside neurons, particularly in neocortical regions [20,23].