Evolving evidence indicates that RJ-related induction of BDNF signaling may alleviate AD symptoms in APP/PS1 mice by reducing cortical and hippocampal levels of BACE1, soluble and insoluble Aβ40 and Aβ42, as well as the number and size of Aβ plaques [28]. This evidence concerns the gene BDNF and Alzheimer disease.