PSEN1 and Alzheimer disease: Immunofluorescence staining and Western blotting revealed that RJ inhibited apoptosis in the brains of AD rabbits and APP/PS1 transgenic mice; the number of activated caspase-3 immunolabeled cells, as well as the covered areas of activated caspase-3, decreased by up to 57% in the cortex and hippocampus of RJ-treated AD models compared with untreated animals [28,70].