However, whether the coagulopathy observed in COVID-19 patients is a consequence of the direct vascular endothelium damage induced by SARS-CoV-2 infection or due to ACE2 blockade remains unknown [100], although Libby and Lüscher have presented COVID-19 as an endothelial disease by providing a unifying pathophysiological picture of the illness [28], in which both inflammation and oxidative stress are relevant players in endothelial function. This evidence concerns the gene ACE2 and COVID-19.