Interestingly, the DVL3 tumours have higher proportion of MDSCs (CD11b+/Gr1+ cells) compared to other syngeneic mouse models, such as 4T1 (breast cancer) CT26 (colorectal cancer) and 4434 (BRAFV600E melanoma) models (p = 0.003. The gene discussed is ITGAM; the disease is breast carcinoma.