Gap junctional intercellular communication (GJIC) significantly contributes to normal physiology, and therefore mutations in Cx genes may cause different diseases [5] such as developmental defects (GJA1), skin diseases (GJA1, GJB2, GJB3, GJB4, and GJB6), hearing loss (GJB2, GJB3, GJB4, and GJB6), and cataracts (GJA3 and GJA8). Here, GJA1 is linked to cataract.