No pathogenic variants in BRCA1, BRCA2 or 13 additional HR-related genes, nor BRCA1 promoter hypermethylation or large genomic rearrangements in BRCA1, were detected in the remaining HRD tumor (case 48) nor in the two HRI tumors (case 38 and 39). The gene discussed is BRCA1; the disease is neoplasm.