Different Hp genotypes are associated with different oxidative conditions; thus, proper sample collection is crucial in human studies investigating the cardioprotective effects of vitamin E. A meta-analysis of the Heart Outcomes Prevention Evaluation (HOPE) trial and the Israel Cardiovascular Events Reduction with Vitamin E (ICARE) study revealed significant reductions in cardiovascular death, MI, and stroke (OR 0.58, 95% CI 0.40, 0.86; p = 0.006) in diabetic individuals with the Hp 2-2 genotype supplemented with vitamin E compared to diabetics with the Hp 1-1 or Hp 2-1 genotype [243]. This evidence concerns the gene HP and Stroke.