NOTCH1 and acute lymphoblastic leukemia: Moellering and colleagues (2009) were the first to demonstrate that a hydrocarbon-stapled peptide derived from a dominant negative form MAML1 known as SAHM1 competitively bound Notch1-CSL transcriptional complex to repress Notch1 target gene expression in T-cell acute lymphoblastic leukemia (T-ALL) [127].