KLK3 and cancer: In a very early trial, Lasalvia-Prisco et al. [160] (Table 8) demonstrated that combined short-term ascorbic acid–menadione therapy produced an immediate drop in both tumor cell numbers and PSA concentrations among men with PCa, suggesting that autoschizis (cancer cell death characterized by a reduction in cell size that occurs due to the loss of cytoplasm through self-excision) can also be induced.