KLK3 and posterior cortical atrophy: In a tertiary prevention placebo-controlled trial, Schröder et al. [188] (Table 9) demonstrated that supplementation with soy, isoflavones, lycopene, silymarin, and antioxidants increased PSA doubling time by 2.6 (from 445 to 1150 days) among men with a history of PCa and rising PSA post-radical prostatectomy or radiotherapy.