KLK3 and posterior cortical atrophy: Although individual RCTs might advocate for the efficacy of flavonoids in reducing PSA concentrations and PCa risk, a 2014 meta-analysis of RCTs indicated that the consumption of soy products or isoflavones did not induce any significant differences in the PSA concentrations between the control and intervention group among men with PCa diagnosis or a clinically identified risk of PCa [82].