The 154 MSH2-negative lesions corresponded to 121 EPCAM-positive (45 precursor lesions and 76 malignant neoplasms) and 33 EPCAM-negative; 17 from the colon were considered informative, and the other 16 cases (14 from the skin, 1 from the lip, and 1 adrenal carcinoma) were considered noninformative due to the lack of EPCAM staining in the normal tissue counterparts. Here, MSH2 is linked to cancer.