In the tumor cell, this reversion to a low immunogenic state is caused by induced expression of programmed cell death ligand-1 (PD-L1) [165,166,167,168,169], increased expression of the immunoregulatory protein Galactin-1 [170], and increased expression of CD47, an immunoregulatory cell marker, on tumor cells, leading to reduced killing by cytotoxic T-cells and macrophages [133]. This evidence concerns the gene CD274 and neoplasm.