Recent studies by Wang and colleagues showed mechanistically that interferon gamma (IFN-γ) released from CD8+ T cells downregulates expression of SLC3A2 and SLC7A11, subunits of the glutamate–cystine antiporter required for cystine uptake, and, as a consequence, promotes tumor cell lipid peroxidation and ferroptosis [120,121]. The gene discussed is CD8A; the disease is neoplasm.