For example, depending on the expression of CD39 and CD73, which are often upregulated in the tumor microenvironment, ATP can be converted into adenosine, the latter tend to position and polarize macrophages into an M2 phenotype, leading to a vascular-endothelial-growth-factor-producing wound-healing-like phenotype in the tissue environment [32]. Here, VEGFA is linked to neoplasm.