Necroptosis, a caspase-independent form of cell death characterized by RIPK1 and RIPK3 activation and phosphorylation of MLKL to induce necrosome formation, produces a lytic type of immunogenic cell death that can release DAMPs and elicit robust inflammation as well as adaptive immune responses against tumor cells by activating DCs [104,105]. Here, RIPK1 is linked to neoplasm.