HAVCR2 and neoplasm: In addition to the TAM receptors, T-cell transmembrane immunoglobulin and mucin receptors (TIM receptors) also comprise a family of PS receptors (TIM-1, TIM-3, and TIM-4) that are expressed on both tumor cells and immune cells, and, like TAM receptors, TIM receptors appear to act as inhibitory receptors that dampen host tumor immunity.