Elegant work pioneered by Kroemer and colleagues observed that certain chemotherapies such as doxorubicin (an anthracycline), certain radiotherapy approaches (focal high dose ionizing radiation), and some physiochemical therapies (hypericin-based photodynamic therapy) could augment tumor immunity through a caspase-dependent immunogenic form of cell death that ultimately lead to DC- and CD8-mediated T cell-mediated immunity [84,85,86]. This evidence concerns the gene CD8A and neoplasm.