For example, the rapid growth of tumors and increased expression of angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin (ANGPT1) can destabilize the tumor vasculature, causing improper formation and hemorrhaging of newly formed blood vessels within the tumor microenvironment leading to poor delivery of oxygen and hypoxic conditions [124,125]. This evidence concerns the gene ANGPT1 and neoplasm.