In addition to immunogenic cell death, whereby caspases are activated concomitantly by the intrinsic apoptosome pathway, as well as release danger and immunogenic constituents that act dominantly, other forms of cell death that include necroptosis, pyroptosis, and ferroptosis achieve cell demise independently of classical executioner caspase 3 and 7 activation and, in principle, spare the tumor microenvironment the post-caspase and the pro-tumorigenic events described above. Here, CASP3 is linked to neoplasm.