In addition to the TAM receptors, T-cell transmembrane immunoglobulin and mucin receptors (TIM receptors) also comprise a family of PS receptors (TIM-1, TIM-3, and TIM-4) that are expressed on both tumor cells and immune cells, and, like TAM receptors, TIM receptors appear to act as inhibitory receptors that dampen host tumor immunity. The gene discussed is TIMD4; the disease is neoplasm.