SF3B1 and melanoma: Conversely, non-cutaneous melanomas have significantly lower numbers of mutations: Acral melanomas have, in about 15–20% of the cases, mutations in BRAF, NRAS, and KIT [51]; mucosal melanomas display KIT mutations in about 15% of the cases (primarily in genitourinary or anal forms) but rarely present mutations in BRAF and NRAS [52]; and uveal melanomas have distinct genomic patterns, presenting mutations either in GNAQ or GNA11 in > 90% of the cases while BAP1, SF3B1, and EIFAX are distinct subsets [53,54,55].