Previous studies revealed that this enzyme displays a wide number of substrates, including the platelet derived growth factor (PDGF) receptor [86], insulin receptor [87], Ephrin A2 (EphA2) [88,89], and several non-receptor proteins, such as proto-oncogene tyrosine-protein kinase Src (Src) [90], focal adhesion kinase (FAK) [91], caveolin [92], signal transducer and activator of transcription 5 (STAT5) [93], β-catenin [94], and p190RhoGAP [95], thereby modulating key signaling pathways involved in tumor growth, differentiation, migration, and invasion [85,89]. Here, PTK2 is linked to neoplasm.