Data published in the Cancer Genome Atlas (TCGA) Network classify cutaneous melanomas into four genetic subgroups on the basis of the most frequently mutated genes involved in the mitogen-activated protein kinase (MAPK) pathway: BRAF, RAS (N-H-K), NF1, and triple wild-type (WT) melanomas [40,41]. The gene discussed is NF1; the disease is cutaneous melanoma.