K-Ras-driven myeloid malignancy and pancreatic cancer development mediated by IL-6 signaling and dependent on myeloid malignancy and pancreatic cancer development were shown to be dependent on mitochondrial activity through serine phosphorylation of STAT3, which enhance ETC activity and ATP production [41,66,97,100]. This evidence concerns the gene IL6 and familial pancreatic carcinoma.