Other research in vivo mouse model and in vitro SCC-25 and CAL 27 human tongue SCC cell lines focusing on P. gingivalis and F. nucleatum observed the same results that by triggering Toll-like receptor (TLR) signaling, IL-6 production increased, and then activated STAT3, which induced important effectors such as cyclinD1, driving cancer cells to grow [47]. Here, STAT3 is linked to cancer.