In the present study, we explored the clinical significance of HIF-1α target gene MTDH, IL-10, CXCL12, CCL2, VEGF, MMP2, LOX, and C-X-C chemokine receptor type 4 (CXCR4) in breast cancer, using RNA-seq datasets from open sources, and further validated these findings in our own breast cancer cohort by immunohistochemistry. This evidence concerns the gene CXCL12 and breast carcinoma.