Nivolumab administered in the next line of treatment to patients with advanced NSCLC resulted in a 13.4% overall survival in a 5-year follow-up [20], while pembrolizumab used in such cases resulted in a 15.5% overall survival and 29.6% in previously untreated patients showing high PD-L1 expression [21]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.