This complete absence of the physiological colonization resistance against C. coli in conventional mice prompted us in our actual study to further unravel the triangle relationship (“ménage-à-trois”) between the pathogen, the vertebrate host immunity, and the intestinal microbiota of murine versus human origin in a clinical acute campylobacteriosis model by using microbiota-depleted IL-10−/− mice. Here, IL10 is linked to campylobacteriosis.