Moreover, pharmacologic and genetic studies support the significance of P2X4 in cognitive function (for a detailed review on P2X modulators in disease, see [12]); P2X4 positive allosteric modulators (e.g., ivermectin and moxidectin) have been shown to reduce ethanol intake in wildtype, [13,14] and internalization-deficient P2X4 knock-in mice, which display increased surface expression of P2X4, demonstrate that P2X4 regulates anxiety and memory processes [15]. Here, P2RX4 is linked to Anxiety.