Although, analyzing the mutation status of the components of the PI3K/Akt and MAPK/ERK pathways in the tumor tissues under this study was not plausible, the hyperphosphorylation of YB-1 and of ERK1/2 in 5 out of 6 ductal carcinoma tissues was observed. This evidence concerns the gene AKT1 and breast ductal adenocarcinoma.