LDLR and Hypercholesterolemia: Nonetheless, in recent years, three novel single nucleotide polymorphisms [LDLR UTR′3 c.*52 A/G (rs14158), LDLR UTR′3 c.*504 A/G (rs2738465), and LDLR UTR′3 c.* 773 A/G (rs2738466)] in the 3′ untranslated region (UTR′3) of the LDLR gene (located in p13.1-13.3 of the chromosome 19) have been associated with higher levels of LDL-C and a greater risk of the developing hypercholesterolemia, the principal cardiovascular risk factor in atherosclerosis [9,10,11].