In our study, we found that groups (LS, LLC and MMR-proficient) did not differ for personal history of cancer (probably because EC is a sentinel event in the population), surgical approach, histology (the majority are endometrioid), grade, lymph node metastasis, synchronous EC and ovarian cancer, type and site of recurrence; however some peculiarities must be underlined. This evidence concerns the gene MRC1 and cancer.