TNF and allergic disease: Studies on pathophysiology of an allergic reaction have indicated the potential role of eosinophil-derived neurotoxin (EDN), representing the activation and degranulation of eosinophils and tumor necrosis factor α (TNFα) involved in the process of intestinal epithelial cell damage, increased intestinal permeability, and mucosal infiltration by leukocytes [12,13,14,15].