Furthermore, α-syn also has an inhibitory effect on the acetylation of α-tubulin via a SIRT2-related mechanism, impairing microtubule (MT) stability and contributing to PD pathology (Figure 3A), and the SIRT2 inhibitor AK-1 partially reverses the reduction in acetylation of α-tubulin mediated by α-syn and restores MT stability [65]. Here, SIRT2 is linked to Parkinson disease.