According to the FISH analysis, most CML cell lines revealed at least two fluorescent signals for TERT and TERC genes with only KU-812 cells presented in some of the nuclei a single copy of TERT gene (Figure 3a), which also was confirmed by CNV analysis of NGS data for most of the cell lines, except KU-812 (Supplementary Table S2). This evidence concerns the gene TERT and chronic myelogenous leukemia, BCR-ABL1 positive.