TSPAN8 and neoplasm: Some tetraspanins such as CD9, CD82, and CD151 are present in almost every EV subtype, while other tetraspanin members are only expressed in particular cell lines and tissues, such as Tssc6 in hematopoietic cells [112], CD37 and CD53 in immune cells [113], and Tetraspanin-8 (Tspan8) in tumor cells [114].