SLC7A11 and neoplasm: As a unit of system xc−, emerging evidence supports that the solute carrier family 7 member 11 (SLC7A11/xCT) is highly expressed in several tumor cells and attenuates erastin-induced ferroptosis.2, 3, 4 An epigenetic decrease of histone H2A ubiquitination represses SLC7A11 expression and decreases occupancy on the promoter of SLC7A11 that facilitates ferroptotic processes.5