LRP5 and atherosclerosis: Also altered in response to serum from PWH was LRP5, a member of the LDL receptor superfamily associated with inflammatory macrophages in advanced atherosclerotic lesions [75], ST14, a mediator of extracellular matrix degradation and infiltration of plaque macrophages in atherosclerosis [76], and CD1D, which codes for an MHC-related surface receptor that binds and presents lipid antigens and participates in PPARγ activation via oxidized cholesterol [77].