As the renal PLA2R expression is significantly correlated to anti-PLA2R Ab levels, and since this autoantibody level is associated with the non-remission outcome, this apparently paradoxical finding can be explained by the fact that lower mRNA levels induce less anti-PLA2R Ab and could be predictive of a better outcome despite its association with a baseline renal failure. The gene discussed is PLA2R1; the disease is kidney failure.