APOE and atherosclerosis: More recently, using ApoE-/- mice on a western diet, a mouse model of nonalcoholic fatty levers disease [12, 13] and atherosclerosis [14], we further demonstrated that the detrimental effects of nicotine delivered through e-cigarettes (2.4% nicotine) at high dosages that led to equivalent serum cotinine levels found in heavy smokers [42] on the heart [16].