MMP1 and cancer: In addition, co-transfection of MDA231-TGL cells with miR-202-3p and MMP1 siRNA rescued the effect of miR-202-3p inhibition on the transmigrative abilities of cancer cells (Fig 4E) and restored normal TEER values and junctions expression similar to the control group in the brain endothelium (Fig 4F and 4G).