MMP1 can be directly targeted and regulated by micro-RNAs including miR-623 in pancreatic cancer cells [26], miR-361-5p in breast cancer [27], miR-330-5p in eosophageal adenocarcinoma [28], miR-222 in fibroblasts and tongue squamous cell carcinoma [29, 30], miR-675 in chondrocytes, miR-526b in skin cells [31] and miR-202-3p in scleroderma fibrosis [32]. This evidence concerns the gene MMP1 and breast carcinoma.