While average age, BMI, or years since diagnosis did not significantly differ between cohorts (Fig 6B–6D), physically active gout patients had over 12-fold fewer gout flares per year (p<0.01; Fig 6E), 10-fold less CRP (p<0.01; Fig 6F), a 4.6-fold decrease in perceived pain at the time of visit (p<0.01; Fig 6G), and a 2.8-fold decrease in perceived pain over the past 4-week period (p<0.05; Fig 6H). Here, CRP is linked to gout.