NRP1 and oral cavity squamous cell carcinoma: Another study by Shahrabi-Farahani et al. revealed significant up-regulation of NRP-1 in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) and showed increased expression of NRP-1 in dysplastic tongue epithelium and OSCC not only within the basal but also throughout proliferating epithelial layers [17].