NRs play an important role in liver diseases and they are key modulators in the onset and progression NAFLD, including the peroxisome proliferator-activated receptors (PPAR) α/β/γ; liver X receptors (LXR) α/β; farnesoid X receptors (FXR); constitutive androstane receptor (CAR); and pregnane X receptor (PXR). The gene discussed is NR1H4; the disease is liver disorder.