While the association between obesity and postmenopausal, estrogen receptor‐positive (ER+) breast cancer is well established, the association between obesity, inflammation, and pre‐menopausal breast cancer remains controversial, particularly in Black/African American women (Yee, Mortimer, Natarajan, Dietze, & Seewaldt, 2020). This evidence concerns the gene ESR1 and obesity due to melanocortin 4 receptor deficiency.