POLR2A and lung adenocarcinoma: As shown in Fig 3a, POLR2A and BCAR1 were significantly increased in lung adenocarcinoma tissues compared to adjacent normal tissues (1.090 ± 0.082 vs. 0.746 ± 0.236, P < 0.05 and 0.810 ± 0.090 vs. 0.589 ± 0.156, P < 0.05, respectively).