PRR14 has been demonstrated to be one of the most upregulated proteins in PD patients’ cerebrospinal fluid (Sinha et al. 2009), as well as in whole blood samples (Scherzer et al. 2007), substantia nigra (Lesnick et al. 2007), and medial substantia nigra (Moran et al. 2006) (Online Resource Figure). The gene discussed is PRR14; the disease is Parkinson disease.