Specifically, CCCTC-binding factor CTCF may potentiate HOXA9 expression through direct binding at the conserved motif between HOXA7 and HOXA9 (CBS7/9) to establish necessary chromatin looping interaction networks in MLLr AML MOLM13 cells (Luo et al., 2018; Luo et al., 2019). Here, HOXA7 is linked to acute myeloid leukemia.