In contrast, Ghasemi et al. reported that HOXA gene expression was maintained in the CTCF-binding site deletion mutants derived from AML OCI-AML3 cells, suggesting that transcriptional activity at the HOXA locus in NPM1-mutant AML cells does not require long-range CTCF-mediated chromatin interactions (Ghasemi et al., 2020). The gene discussed is NPM1; the disease is acute myeloid leukemia.