A recent European study analyzing 14 biomarkers were analyzed in sinonasal tissue identified 10 clusters showed IL-5 levels to be important.22 Nasal polyposis tissue has an increased immune response to S. aureus enterotoxins, resulting in more pronounced eosinophilic inflammation and higher total IgE production in the tissue of patients affected by CRSwNP.24,25 For example, SAE-specific IgE-positive nasal polyps show more severe eosinophilic inflammation compared to controls. The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.